New interventions to control malaria depend on a deep understanding of the parasite that causes the disease. The PlasmoGEM project produces free genetic tools for research on malaria parasites. We also use the reagents in genetic screens to identify parasite gene functions at scale. The purpose of this database is to share data generated by the project.
The largest reagent set is from Plasmodium berghei ANKA, a model species infecting rodents, but reagents for other Plasmodium species are available. To search for available plasmids, view vector designs and download their sequence, go to PlasmoGEM Vectors.
Barcoded PlasmoGEM reagents have so far enabled nearly a dozen genetic screens in P. berghei, resulting in a rich resource of functional data from different life cycle stages. To view, search and download >12,000 P. berghei phenotype measurements, go to PlasmoGEM Phenotypes.
PlasmoGEM was an initiative of the Sanger Institute Malaria Programme and funded by the Wellcome Trust until 2020.
Reagents continue to be distributed from the Sanger Institute.
Following the move of the Billker lab to Umeå University, this database was created with funding from the European Research Council and the Knut and Alice Wallenberg Foundation, who both continue to support phenotyping work in Umeå.
For more scientific and historic background, visit the “about” menu from this page
.For technical details on vectors and phenotypes, go to the “information” menu in the respective section of the database.
